Influence of Gut Microbiota on Mental Health via Neurotransmitters: A Review


  • Ting Liu Knowledge Representation and Reasoning (KR&R) Group, Vrije Universiteit Amsterdam, Amsterdam, De Boelelaan 1085, 1081 HV, The Netherlands
  • K. Anton Feenstra Center for Integrative Bioinformatics VU (IBIVU), Vrije Universiteit Amsterdam, Amsterdam, De Boelelaan 1085, 1081 HV, The Netherlands
  • Jaap Heringa Amsterdam Institute for Molecules Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, De Boelelaan 1085, 1081 HV, The Netherlands
  • Zhisheng Huang Knowledge Representation and Reasoning (KR&R) Group, Vrije Universiteit Amsterdam, Amsterdam, De Boelelaan 1085, 1081 HV, The Netherlands



Gut microbiota, Neurotransmitter, Mental disorders, Microbiota-gut-brain axis


Mental disorders related to the imbalance of neurotransmitters, which are substantially affected by gut microbiota. Gut microbiota impacts on mental health by regulating the level of neurotransmitters in the host. To understand the influence of gut microbiota on mental health via neurotransmitters, we conducted a literature survey on the association between gut microbiota and neurotransmitters. We identified trustworthy evidences by critically appraising the related articles in terms of its evidence level. This paper provides a fairly comprehensive list of gut microbiota strains that can regulate neurotransmitters. Gut microbiota, neurotransmitters and mental disorders influence each other in a bidirectional way which form a triangle relationship. Understanding the triangle relationship benefits for the treatment of mental disorders. People who have experienced mental disorders may cure in the future by altering gut microbiota.


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How to Cite

Liu T, Feenstra KA, Heringa J, Huang Z. Influence of Gut Microbiota on Mental Health via Neurotransmitters: A Review. JAIMS [Internet]. 2021 May 5 [cited 2023 Jun. 8];1(1-2):1-14. Available from: